What is T.D.M.S. 2000™?

T.D.M.S 2000™ is a software package for therapeutic drug monitoring. It has a 15 year track record of clinical use. T.D.M.S. has proven itself to be on the cutting edge of software technology for clinical pharmacokinetics. T.D.M.S. 2000 is compatible with Windows XP, 2000, 98, 95, ME, Vista and can be used over a network with a shared database.

Version 10.01 has now been released. It was released on Jan. 18. 2010. Paid subscribers can download the latest file under the download section. To try the software for free, please follow the following link for a free demo version 10.01.

Download a Free Demo Version of T.D.M.S. 2000™.

Prominent features of T.D.M.S. 2000™

• New! Non-steady-state phenytoin curve fitting
• Bayesian curve fitting
• Nonlinear least-squares curve fitting
• Population estimates for 15 commonly monitored drugs
• User’s Choice option fits any one-compartment drug
• Easy and intuitive data entry and navigation screens
• Access* compatible database for storage and retrieval of patient data
• Can share a common database among workstations on a network
• Customizable reports with virtually unlimited printer compatibility
• Fully documented User Manual
• Compatible with Windows XP, 2000, 98, 95, ME and Vista.

Bayes vs. Population Graphing

What's New in T.D.M.S. 2000™ Version 10.01

• One-Step Updating. Now a group of computers can be updated annually at one location. By checking the “Use Shared License” checkbox on the opening screen, you can direct each workstation to share one config.dat file that contains the expiration date of your program. In this way, you will only have to update one location each year when you renew your license rather than each computer separately. If the box is unchecked, the config.dat file will need to be located on the individual computer just as it has been on previous versions. 
• Bulk Record Deletion. Large numbers of records can be deleted by date from the database search screen. You can then use the new “Delete All” button on the next screen to reduce the size of your database.
  
• Unit Defaults. Patient height and weight now default to metric units (i.e., cm and kg) rather than English units on the patient demographics input screen.
  Changed Bioavailability Display. The oral bioavailability (F) is always displayed when more than one route is chosen. IV bioavailability is always 100%. 
  
• Phenytoin Dosage Form Entry. Phenytoin  dosage forms are now all entered on the spreadsheet using the letters C, S or T for (C)apsule, (S)uspension, (T)ablet for oral forms. This change allows more flexibility in mixing oral dosage forms in a patient and more accurately tracks salt form values. 
  
• Improved Program Flow. After fitting serum concentrations and making estimates of serum concentrations using fitted pharmacokinetic parameters on the Routine or Detailed Analysis screens, pressing the “Back” button returns you to the Factors screen. This ensures that all factors are considered in the starting population values on the next screen. 
  
• New LBW & Adjusted Weight equation. The equation for calculating lean body weight (total weight minus fat weight) in adults has been changed to an improved equation (Han PY et al. Clin Pharmacol Ther 2007;82:505-8). T.D.M.S. 2000 now defines adjusted body weight as follows: TBW for patients weighing less than their IBW, IBW for patient at or above their IBW, and LBW at and beyond the point where IBW exceeds LBM. 
• Revised CLcr Calculation. The Cockroft-Gault equation now uses the new adjusted weight. Using LBW in morbid obesity results in a more accurate prediction of CLcr in this population (Demirovic JA et al. Am J Health Syst Pharm. 2009;66:642-8). The  calculated CLcr will be lower in morbidly obese patients, thereby moderating the increase in drug clearance of renally cleared drugs.

What's New in T.D.M.S. 2000™ Version 8.1

• Time zero is displayed on all graphs
• population and entered serum concentrations are printed on the report
  Two oral dosage forms can be used simultaneously in phenytoin forecasting
• “Back” button in phenytoin returns to spreadsheet without invoking curve fitting
• Detailed phenytoin analysis display is reorganized to improve clarity
  

What's New in T.D.M.S. 2000™ Version 7

• Non-steady-state phenytoin curve fitting.
• Updated calculation of procainamide clearance
  
• Improved parameter estimates for obese patients
  
• Lag time for oral absorption in User’s Choice
  
• More factors that modify vancomycin parameters