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Download User Guide Manual

TDMS Instructions.pdf


Precise PK User Manual.pdf


Precise PK Download Link

Windows: Precise PK Installer v15.04.14

Mac: Precise PK Disk Image v15.04.21

Different version update

  • One-Step Updating. Now a group of computers can be updated annually at one location. By checking the “Use Shared License” checkbox on the opening screen, you can direct each workstation to share one config.dat file that contains the expiration date of your program. In this way, you will only have to update one location each year when you renew your license rather than each computer separately. If the box is unchecked, the config.dat file will need to be located on the individual computer just as it has been on previous versions. 
  • Bulk Record Deletion. Large numbers of records can be deleted by date from the database search screen. You can then use the new “Delete All” button on the next screen to reduce the size of your database.
  • Unit Defaults. Patient height and weight now default to metric units (i.e., cm and kg) rather than English units on the patient demographics input screen.
    Changed Bioavailability Display. The oral bioavailability (F) is always displayed when more than one route is chosen. IV bioavailability is always 100%. 
  • Phenytoin Dosage Form Entry. Phenytoin  dosage forms are now all entered on the spreadsheet using the letters C, S or T for (C)apsule, (S)uspension, (T)ablet for oral forms. This change allows more flexibility in mixing oral dosage forms in a patient and more accurately tracks salt form values. 
  • Improved Program Flow. After fitting serum concentrations and making estimates of serum concentrations using fitted pharmacokinetic parameters on the Routine or Detailed Analysis screens, pressing the “Back” button returns you to the Factors screen. This ensures that all factors are considered in the starting population values on the next screen. 
  • New LBW & Adjusted Weight equation. The equation for calculating lean body weight (total weight minus fat weight) in adults has been changed to an improved equation (Han PY et al. Clin Pharmacol Ther 2007;82:505-8). T.D.M.S. 2000 now defines adjusted body weight as follows: TBW for patients weighing less than their IBW, IBW for patient at or above their IBW, and LBW at and beyond the point where IBW exceeds LBM. 
  • Revised CLcr Calculation. The Cockroft-Gault equation now uses the new adjusted weight. Using LBW in morbid obesity results in a more accurate prediction of CLcr in this population (Demirovic JA et al. Am J Health Syst Pharm. 2009;66:642-8). The  calculated CLcr will be lower in morbidly obese patients, thereby moderating the increase in drug clearance of renally cleared drugs.
  • Time zero is displayed on all graphs
  • population and entered serum concentrations are printed on the report
    Two oral dosage forms can be used simultaneously in phenytoin forecasting
  • “Back” button in phenytoin returns to spreadsheet without invoking curve fitting
  • Detailed phenytoin analysis display is reorganized to improve clarity
  • Non-steady-state phenytoin curve fitting.
  • Updated calculation of procainamide clearance
  • Improved parameter estimates for obese patients
  • Lag time for oral absorption in User's Choice
  • More factors that modify vancomycin parameters

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